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Structural highlights

Function

MTRR_NEIGO Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents (PubMed:8196548). Represses transcription of the mtrCDE-encoded efflux pump by binding within the mtrCDE promoter (PubMed:9209024, PubMed:23221802). Also negatively regulates the expression of farR, by binding to its promoter region, leading indirectly to the positive regulation of expression of the farAB-encoded efflux pump (PubMed:14645274).^{[1] [2] [3] [4]}

References

1. ↑ Lee EH, Rouquette-Loughlin C, Folster JP, Shafer WM. FarR regulates the farAB-encoded efflux pump of Neisseria gonorrhoeae via an MtrR regulatory mechanism. J Bacteriol. 2003 Dec;185(24):7145-52. doi: 10.1128/jb.185.24.7145-7152.2003. PMID:14645274 doi:http://dx.doi.org/10.1128/jb.185.24.7145-7152.2003
2. ↑ Zalucki YM, Dhulipala V, Shafer WM. Dueling regulatory properties of a transcriptional activator (MtrA) and repressor (MtrR) that control efflux pump gene expression in Neisseria gonorrhoeae. MBio. 2012 Dec 4;3(6):e00446-12. doi: 10.1128/mBio.00446-12. PMID:23221802 doi:http://dx.doi.org/10.1128/mBio.00446-12
3. ↑ Pan W, Spratt BG. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol Microbiol. 1994 Feb;11(4):769-75. doi: 10.1111/j.1365-2958.1994.tb00354.x. PMID:8196548 doi:http://dx.doi.org/10.1111/j.1365-2958.1994.tb00354.x
4. ↑ Lucas CE, Balthazar JT, Hagman KE, Shafer WM. The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae. J Bacteriol. 1997 Jul;179(13):4123-8. doi: 10.1128/jb.179.13.4123-4128.1997. PMID:9209024 doi:http://dx.doi.org/10.1128/jb.179.13.4123-4128.1997