8tgx

Structural highlights

Function

LGG1_CAEEL Ubiquitin-like modifier involved in autophagy and essential for dauer development and life-span extension (PubMed:12958363, PubMed:20523114). Plays a role in mitophagy (PubMed:25896323).^{[1] [2] [3]}

References

1. ↑ Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 2003 Sep 5;301(5638):1387-91. PMID:12958363 doi:http://dx.doi.org/10.1126/science.1087782
2. ↑ Alberti A, Michelet X, Djeddi A, Legouis R. The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans. Autophagy. 2010 Jul;6(5):622-33. doi: 10.4161/auto.6.5.12252. Epub 2010 Jul 1. PMID:20523114 doi:http://dx.doi.org/10.4161/auto.6.5.12252
3. ↑ Palikaras K, Lionaki E, Tavernarakis N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature. 2015 May 28;521(7553):525-8. doi: 10.1038/nature14300. Epub 2015 Apr 20. PMID:25896323 doi:http://dx.doi.org/10.1038/nature14300