| Structural highlights
Disease
CDCA7_HUMAN ICF syndrome. The disease may be caused by variants affecting the gene represented in this entry.
Function
CDCA7_HUMAN Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.[1] [2] [3] [4]
References
- ↑ Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV. A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. J Biol Chem. 2001 Dec 21;276(51):48276-84. PMID:11598121 doi:10.1074/jbc.M107357200
- ↑ Osthus RC, Karim B, Prescott JE, Smith BD, McDevitt M, Huso DL, Dang CV. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Cancer Res. 2005 Jul 1;65(13):5620-7. PMID:15994934 doi:10.1158/0008-5472.CAN-05-0536
- ↑ Goto Y, Hayashi R, Muramatsu T, Ogawa H, Eguchi I, Oshida Y, Ohtani K, Yoshida K. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta. 2006 Jan-Feb;1759(1-2):60-8. PMID:16580749 doi:10.1016/j.bbaexp.2006.02.004
- ↑ Gill RM, Gabor TV, Couzens AL, Scheid MP. The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. Mol Cell Biol. 2013 Feb;33(3):498-513. PMID:23166294 doi:10.1128/MCB.00276-12
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