8uav

Structural highlights

Function

Q7DH26_ECO57 The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.[ARBA:ARBA00003218]RISB2_BRUAB Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. Displays low catalytic activity in comparison with the isozyme RibH1.^{[1] [2]}

References

1. ↑ Goldbaum FA, Velikovsky CA, Baldi PC, Mortl S, Bacher A, Fossati CA. The 18-kDa cytoplasmic protein of Brucella species --an antigen useful for diagnosis--is a lumazine synthase. J Med Microbiol. 1999 Sep;48(9):833-9. PMID:10482294
2. ↑ Klinke S, Zylberman V, Vega DR, Guimaraes BG, Braden BC, Goldbaum FA. Crystallographic studies on decameric Brucella spp. Lumazine synthase: a novel quaternary arrangement evolved for a new function? J Mol Biol. 2005 Oct 14;353(1):124-37. PMID:16165152 doi:http://dx.doi.org/10.1016/j.jmb.2005.08.017