8ug6

Structural highlights

Function

OTOP2_MOUSE Proton-selective ion channel open at neutral pH (PubMed:29371428, PubMed:35920807, PubMed:37053086). Actives at neutral and alkaline extracellular pH, likely participates in some alkali-related physiological activities (PubMed:35920807, PubMed:37053086).^{[1] [2] [3]}

References

1. ↑ Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. An evolutionarily conserved gene family encodes proton-selective ion channels. Science. 2018 Mar 2;359(6379):1047-1050. PMID:29371428 doi:10.1126/science.aao3264
2. ↑ Teng B, Kaplan JP, Liang Z, Krieger Z, Tu YH, Burendei B, Ward AB, Liman ER. Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels. Elife. 2022 Aug 3;11:e77946. PMID:35920807 doi:10.7554/eLife.77946
3. ↑ Teng B, Kaplan JP, Liang Z, Chyung KS, Goldschen-Ohm MP, Liman ER. Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus. Elife. 2023 Apr 13;12:e85317. PMID:37053086 doi:10.7554/eLife.85317