8uk9

Structural highlights

Function

LOADS_BPT4 Forms the sliding-clamp-loader together with the small subunit (PubMed:10585481). The clamp loader holds the clamp in an open conformation and places it onto the DNA (PubMed:22194570).[HAMAP-Rule:MF_04163]^{[1] [2]}

References

1. ↑ Janzen DM, Torgov MY, Reddy MK. In vitro reconstitution of the bacteriophage T4 clamp loader complex (gp44/62). J Biol Chem. 1999 Dec 10;274(50):35938-43. PMID:10585481 doi:10.1074/jbc.274.50.35938
2. ↑ Kelch BA, Makino DL, O'Donnell M, Kuriyan J. How a DNA polymerase clamp loader opens a sliding clamp. Science. 2011 Dec 23;334(6063):1675-80. PMID:22194570 doi:10.1126/science.1211884