8vjg
From Proteopedia
Jump to: navigation, search
proteopedia linkproteopedia linkHuman R14A Pin1 covalently bound to inhibitor 164A10
Structural highlights
FunctionPIN1_HUMAN Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.[1] [2] [3] References
|
Retrieved from "http://52.214.119.220/wiki/index.php/8vjg"