Structural highlights
Function
ACTS_RABIT Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Publication Abstract from PubMed
Gelsolin is the prototypical member of a family of Ca (2+) -dependent F-actin severing and capping proteins. A structure of Ca (2+) -bound full-length gelsolin at the barbed end shows domains G1G6 and the inter-domain linkers wrapping around F-actin. Another structure shows domains G1G3, a fragment produced during apoptosis, on both sides of F-actin. Conformational changes that trigger severing occur on one side of F-actin with G1G6 and on both sides with G1G3. Gelsolin remains bound after severing, blocking subunit exchange.
Mechanism of Actin Filament Severing and Capping by Gelsolin.,Barrie KR, Rebowski G, Dominguez R bioRxiv [Preprint]. 2024 Sep 23:2024.09.10.612341. doi: , 10.1101/2024.09.10.612341. PMID:39345426[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Barrie KR, Rebowski G, Dominguez R. Mechanism of Actin Filament Severing and Capping by Gelsolin. bioRxiv [Preprint]. 2024 Sep 23:2024.09.10.612341. PMID:39345426 doi:10.1101/2024.09.10.612341