Structural highlights
Function
S13A2_HUMAN Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:9668069, PubMed:8967342). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:8967342, PubMed:9668069, PubMed:10894787). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity).[UniProtKB:Q9ES88][1] [2] [3]
References
- ↑ Yao X, Pajor AM. The transport properties of the human renal Na(+) under voltage-clamp conditions. Am J Physiol Renal Physiol. 2000 Jul;279(1):F54-64. PMID:10894787 doi:10.1152/ajprenal.2000.279.1.F54
- ↑ Pajor AM. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol. 1996 Apr;270(4 Pt 2):F642-8. PMID:8967342 doi:10.1152/ajprenal.1996.270.4.F642
- ↑ Pajor AM, Hirayama BA, Loo DD. Sodium and lithium interactions with the Na+/Dicarboxylate cotransporter. J Biol Chem. 1998 Jul 24;273(30):18923-9. PMID:9668069 doi:10.1074/jbc.273.30.18923
