8waz

Structural highlights

Function

AAMAT_AMAPH Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:4865716, PubMed:363352, PubMed:7642577, PubMed:8702941).^{[1] [2] [3] [4] [5]}

References

1. ↑ Wieland T, Faulstich H. Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem. 1978 Dec;5(3):185-260. PMID:363352
2. ↑ Wieland T. Poisonous principles of mushrooms of the genus Amanita. Four-carbon amines acting on the central nervous system and cell-destroying cyclic peptides are produced. Science. 1968 Mar 1;159(3818):946-52. PMID:4865716
3. ↑ Chafin DR, Guo H, Price DH. Action of alpha-amanitin during pyrophosphorolysis and elongation by RNA polymerase II. J Biol Chem. 1995 Aug 11;270(32):19114-9. PMID:7642577
4. ↑ Rudd MD, Luse DS. Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes. J Biol Chem. 1996 Aug 30;271(35):21549-58. PMID:8702941
5. ↑ Li P, Deng W, Li T. The molecular diversity of toxin gene families in lethal Amanita mushrooms. Toxicon. 2014 Jun;83:59-68. doi: 10.1016/j.toxicon.2014.02.020. Epub 2014 Mar 5. PMID:24613547 doi:http://dx.doi.org/10.1016/j.toxicon.2014.02.020