8x53

Structural highlights

Disease

NICA_HUMAN Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.

Function

NICA_HUMAN Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.