8xa0

Structural highlights

Function

LTP_HHV11 Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.[HAMAP-Rule:MF_04044]^{[1] [2] [3] [4] [5] [6] [7] [8] [9]}

References

1. ↑ Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL. A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol. 2005 Dec;79(24):15582-5. PMID:16306630 doi:10.1128/JVI.79.24.15582-15585.2005
2. ↑ Jovasevic V, Liang L, Roizman B. Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus. J Virol. 2008 Apr;82(7):3311-9. PMID:18216103 doi:10.1128/JVI.01919-07
3. ↑ Shanda SK, Wilson DW. UL36p is required for efficient transport of membrane-associated herpes simplex virus type 1 along microtubules. J Virol. 2008 Aug;82(15):7388-94. PMID:18495763 doi:10.1128/JVI.00225-08
4. ↑ Roberts AP, Abaitua F, O'Hare P, McNab D, Rixon FJ, Pasdeloup D. Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1. J Virol. 2009 Jan;83(1):105-16. PMID:18971278 doi:10.1128/JVI.01032-08
5. ↑ Ko DH, Cunningham AL, Diefenbach RJ. The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2). J Virol. 2010 Feb;84(3):1397-405. PMID:19923173 doi:10.1128/JVI.01721-09
6. ↑ Gastaldello S, Hildebrand S, Faridani O, Callegari S, Palmkvist M, Di Guglielmo C, Masucci MG. A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol. 2010 Apr;12(4):351-61. PMID:20190741 doi:10.1038/ncb2035
7. ↑ Cardone G, Newcomb WW, Cheng N, Wingfield PT, Trus BL, Brown JC, Steven AC. The UL36 tegument protein of herpes simplex virus 1 has a composite binding site at the capsid vertices. J Virol. 2012 Apr;86(8):4058-64. PMID:22345483 doi:10.1128/JVI.00012-12
8. ↑ Abaitua F, Hollinshead M, Bolstad M, Crump CM, O'Hare P. A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore. J Virol. 2012 Sep;86(17):8998-9014. PMID:22718835 doi:10.1128/JVI.01209-12
9. ↑ Sandbaumhüter M, Döhner K, Schipke J, Binz A, Pohlmann A, Sodeik B, Bauerfeind R. Cytosolic herpes simplex virus capsids not only require binding inner tegument protein pUL36 but also pUL37 for active transport prior to secondary envelopment. Cell Microbiol. 2013 Feb;15(2):248-69. PMID:23186167 doi:10.1111/cmi.12075