8xe3

Structural highlights

Function

NOMT_NARAP 4'-O-methyltransferase converting norbelladine to 4'-O-methylnorbelladine. 4'-O-methylnorbelladine is a precursor to all Amaryllidaceae alkaloids such as galanthamine, lycorine and haemanthamine, and including haemanthamine- and crinamine-type alkaloids, promising anticancer agents. Can use norbelladine, N-methylnorbelladine and dopamine as substrate, but not caffeic acid, vanillin, 3,4-dihydroxybenzaldehyde and tyramine.^[1]

References

1. ↑ Kilgore MB, Augustin MM, Starks CM, O'Neil-Johnson M, May GD, Crow JA, Kutchan TM. Cloning and characterization of a norbelladine 4'-O-methyltransferase involved in the biosynthesis of the Alzheimer's drug galanthamine in Narcissus sp. aff. pseudonarcissus. PLoS One. 2014 Jul 25;9(7):e103223. PMID:25061748 doi:10.1371/journal.pone.0103223