8y48

Structural highlights

Function

GB_HHV8P Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGAV-ITGB3. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.^{[1] [2] [3]}

References

1. ↑ Pertel PE. Human herpesvirus 8 glycoprotein B (gB), gH, and gL can mediate cell fusion. J Virol. 2002 May;76(9):4390-400. PMID:11932406 doi:10.1128/jvi.76.9.4390-4400.2002
2. ↑ Wang FZ, Akula SM, Sharma-Walia N, Zeng L, Chandran B. Human herpesvirus 8 envelope glycoprotein B mediates cell adhesion via its RGD sequence. J Virol. 2003 Mar;77(5):3131-47. PMID:12584338 doi:10.1128/jvi.77.5.3131-3147.2003
3. ↑ Garrigues HJ, Rubinchikova YE, Dipersio CM, Rose TM. Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor. J Virol. 2008 Feb;82(3):1570-80. PMID:18045938 doi:10.1128/JVI.01673-07