8y6m
From Proteopedia
The structure of Oryza sativa HKT2;1
Structural highlights
FunctionC562_ECOLX Electron-transport protein of unknown function.HKT21_ORYSI Seems to be involved in regulation of potassium-sodium homeostasis (PubMed:11489190, PubMed:11959905, PubMed:12182709, PubMed:12795699). Seems to act as a high-affinity sodium transporter, which mediates increased sodium uptake in roots under potassium deficiency and contributes to sodium accumulation and salt toxicity (PubMed:11489190, PubMed:11959905, PubMed:12182709, PubMed:12795699). Involved in nutritional sodium uptake and distribution in potassium-starved roots to allow plant growth (By similarity). May also act as a potassium transporter (PubMed:11489190, PubMed:11959905, PubMed:12182709, PubMed:12795699). Functions as a sodium-potassium cotransporter (By similarity).[UniProtKB:Q0D9S3][1] [2] [3] [4] Publication Abstract from PubMedThe high-affinity potassium transporters (HKTs), selectively permeable to either Na(+) alone or Na(+)/K(+), play pivotal roles in maintaining plant Na(+)/K(+) homeostasis. Although their involvement in salt tolerance is widely reported, the molecular underpinnings of Oryza sativa HKTs remain elusive. In this study, we elucidate the structures of OsHKT1;1 and OsHKT2;1, representing two distinct classes of rice HKTs. The dimeric assembled OsHKTs can be structurally divided into four domains. At the dimer interface, a half-helix or a loop in the third domain is coordinated by the C-terminal region of the opposite subunit. Additionally, we present the structures of OsHKT1;5 salt-tolerant and salt-sensitive variants, a key quantitative trait locus associated with salt tolerance. The salt-tolerant variant of OsHKT1;5 exhibits enhanced Na(+) transport capability and displays a more flexible conformation. These findings shed light on the molecular basis of rice HKTs and provide insights into their role in salt tolerance. Structural insights into the Oryza sativa cation transporters HKTs in salt tolerance.,Gao R, Jia Y, Xu X, Fu P, Zhou J, Yang G J Integr Plant Biol. 2024 Apr;66(4):700-708. doi: 10.1111/jipb.13632. Epub 2024 , Feb 26. PMID:38409933[5] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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