8yr9
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proteopedia linkproteopedia linkthe Cyro-EM Structure of human SLC26A3
Structural highlights
DiseaseS26A3_HUMAN Congenital chloride diarrhea. The disease is caused by variants affecting the gene represented in this entry. FunctionS26A3_HUMAN Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).[UniProtKB:Q9WVC8][1] [2] [3] [4] References
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