8yta

Structural highlights

Function

PDE8A_HUMAN Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.^[1]

References

1. ↑ Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity. Biochemistry. 2008 Nov 5. PMID:18983167 doi:10.1021/bi801487x