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Structural highlights

Function

C562_ECOLX Electron-transport protein of unknown function.ACH23_CAEEL Betaine receptor that functions as a ligand-gated non-selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA.^{[1] [2]}

References

1. ↑ Rufener L, Bedoni N, Baur R, Rey S, Glauser DA, Bouvier J, Beech R, Sigel E, Puoti A. acr-23 Encodes a monepantel-sensitive channel in Caenorhabditis elegans. PLoS Pathog. 2013;9(8):e1003524. PMID:23950710 doi:10.1371/journal.ppat.1003524
2. ↑ Peden AS, Mac P, Fei YJ, Castro C, Jiang G, Murfitt KJ, Miska EA, Griffin JL, Ganapathy V, Jorgensen EM. Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans. Nat Neurosci. 2013 Dec;16(12):1794-801. PMID:24212673 doi:10.1038/nn.3575