8zon

Structural highlights

Function

PROA_ECOLI Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.[HAMAP-Rule:MF_00412]^{[1] [2]}

References

1. ↑ Hayzer DJ, Leisinger T. Proline biosynthesis in Escherichia coli. Stoichiometry and end-product identification of the reaction catalysed by glutamate semialdehyde dehydrogenase. Biochem J. 1981 Aug 1;197(2):269-74. PMID:7034716 doi:10.1042/bj1970269
2. ↑ Hayzer DJ, Leisinger T. Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase. Eur J Biochem. 1982 Jan;121(3):561-5. PMID:7035170 doi:10.1111/j.1432-1033.1982.tb05823.x