8zt5

Structural highlights

Function

P2RX1_MOUSE ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923).[UniProtKB:P51575]^{[1] [2] [3] [4]}

References

1. ↑ Mulryan K, Gitterman DP, Lewis CJ, Vial C, Leckie BJ, Cobb AL, Brown JE, Conley EC, Buell G, Pritchard CA, Evans RJ. Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. Nature. 2000 Jan 6;403(6765):86-9. PMID:10638758 doi:10.1038/47495
2. ↑ Vial C, Evans RJ. P2X receptor expression in mouse urinary bladder and the requirement of P2X(1) receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle. Br J Pharmacol. 2000 Dec;131(7):1489-95. PMID:11090125 doi:10.1038/sj.bjp.0703720
3. ↑ Lecut C, Frederix K, Johnson DM, Deroanne C, Thiry M, Faccinetto C, Marée R, Evans RJ, Volders PG, Bours V, Oury C. P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation. J Immunol. 2009 Aug 15;183(4):2801-9. PMID:19635923 doi:10.4049/jimmunol.0804007
4. ↑ Darbousset R, Delierneux C, Mezouar S, Hego A, Lecut C, Guillaumat I, Riederer MA, Evans RJ, Dignat-George F, Panicot-Dubois L, Oury C, Dubois C. P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice. Blood. 2014 Oct 16;124(16):2575-85. PMID:25150292 doi:10.1182/blood-2014-04-571679