Structural highlights
Function
TMAT_MYRPR Catalyzes the transport of trimethylamine (TMA) from the environment into the cell (PubMed:33771875). Binds TMA with high affinity, but does not bind trimethylamine N-oxide (TMAO), glycine betaine, carnitine, choline or dimethylsulfoniopropionate (DMSP) (PubMed:33771875). Together with the TMA monooxygenase Mptmm, is part of a two-step metabolic pathway that improves both growth and survival at high hydrostatic pressure (HHP) (PubMed:33771875).[1]
References
- ↑ Qin QL, Wang ZB, Su HN, Chen XL, Miao J, Wang XJ, Li CY, Zhang XY, Li PY, Wang M, Fang J, Lidbury I, Zhang W, Zhang XH, Yang GP, Chen Y, Zhang YZ. Oxidation of trimethylamine to trimethylamine N-oxide facilitates high hydrostatic pressure tolerance in a generalist bacterial lineage. Sci Adv. 2021 Mar 26;7(13). pii: 7/13/eabf9941. doi: 10.1126/sciadv.abf9941., Print 2021 Mar. PMID:33771875 doi:http://dx.doi.org/10.1126/sciadv.abf9941
