Structural highlights
Function
RIC1_YEAST The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment. May also be indirectly involved in the transcription of both ribosomal protein genes and ribosomal RNA.[1] [2] [3]
References
- ↑ Siniossoglou S, Peak-Chew SY, Pelham HR. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. EMBO J. 2000 Sep 15;19(18):4885-94. PMID:10990452 doi:10.1093/emboj/19.18.4885
- ↑ Bensen ES, Yeung BG, Payne GS. Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins. Mol Biol Cell. 2001 Jan;12(1):13-26. PMID:11160819 doi:10.1091/mbc.12.1.13
- ↑ Siniossoglou S, Pelham HR. An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes. EMBO J. 2001 Nov 1;20(21):5991-8. PMID:11689439 doi:10.1093/emboj/20.21.5991
