Structural highlights
Function
YL079_MIMIV
Publication Abstract from PubMed
RNA-guided endonucleases, once thought to be exclusive to prokaryotes, have been recently identified in eukaryotes and are called Fanzors. They are classified into two clades, Fanzor1 and Fanzor2. Here we present the cryo-electron microscopy structure of Acanthamoeba polyphaga mimivirus Fanzor2, revealing its omegaRNA architecture, active site and features involved in transposon-adjacent motif recognition. A comparison to Fanzor1 and TnpB structures highlights divergent evolutionary paths, advancing our understanding of RNA-guided endonucleases.
, PMID:39354233[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Schargel RD, Qayyum MZ, Tanwar AS, Kalathur RC, Kellogg EH. Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily. Nat Struct Mol Biol. 2024 Oct 1. PMID:39354233 doi:10.1038/s41594-024-01394-4