Structural highlights
Function
CXXC1_DROME Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1.[1]
References
- ↑ Ardehali MB, Mei A, Zobeck KL, Caron M, Lis JT, Kusch T. Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. EMBO J. 2011 Jun 21;30(14):2817-28. PMID:21694722 doi:10.1038/emboj.2011.194
