9c65

Structural highlights

Function

SLL11_STAAU Secreted protein that plays a role in the inhibition of host immune system. Targets myeloid cells such as monocytes or granulocytes through binding with sialyllactosamine-containing glycoproteins (PubMed:18045383). Prevents initial rolling of neutrophils toward the site of infection by interacting with host SELPLG (PubMed:18045383). Disrupts neutrophil motility by induction of cell adhesion via interacting with glycans but independently of SELPLG (PubMed:30862940).^{[1] [2]}

References

1. ↑ Chung MC, Wines BD, Baker H, Langley RJ, Baker EN, Fraser JD. The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition. Mol Microbiol. 2007 Dec;66(6):1342-55. PMID:18045383 doi:10.1111/j.1365-2958.2007.05989.x
2. ↑ Chen C, Yang C, Barbieri JT. Staphylococcal Superantigen-like protein 11 mediates neutrophil adhesion and motility arrest, a unique bacterial toxin action. Sci Rep. 2019 Mar 12;9(1):4211. PMID:30862940 doi:10.1038/s41598-019-40817-x