9c6g
From Proteopedia
Mcm double hexamer from human
Structural highlights
DiseaseMCM4_HUMAN Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency. The disease is caused by mutations affecting the gene represented in this entry. FunctionMCM4_HUMAN Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.[1] [2] References
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Categories: Homo sapiens | Large Structures | Lin Q | Liu C | Xu N
