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Structural highlights

Function

KIN17_HUMAN Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.[UniProtKB:Q8K339]^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Biard DS, Miccoli L, Despras E, Frobert Y, Creminon C, Angulo JF. Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. J Biol Chem. 2002 May 24;277(21):19156-65. PMID:11880372 doi:10.1074/jbc.M200321200
2. ↑ Miccoli L, Biard DS, Créminon C, Angulo JF. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. Cancer Res. 2002 Oct 1;62(19):5425-35 PMID:12359749
3. ↑ Biard DS, Miccoli L, Despras E, Harper F, Pichard E, Créminon C, Angulo JF. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. Mol Cancer Res. 2003 May;1(7):519-31 PMID:12754299
4. ↑ Miccoli L, Biard DS, Frouin I, Harper F, Maga G, Angulo JF. Selective interactions of human kin17 and RPA proteins with chromatin and the Nucleic Acids Res. 2003 Jul 15;31(14):4162-75. PMID:12853634 doi:10.1093/nar/gkg459
5. ↑ Miccoli L, Frouin I, Novac O, Di Paola D, Harper F, Zannis-Hadjopoulos M, Maga G, Biard DS, Angulo JF. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. Mol Cell Biol. 2005 May;25(9):3814-30. PMID:15831485 doi:10.1128/MCB.25.9.3814-3830.2005
6. ↑ le Maire A, Schiltz M, Stura EA, Pinon-Lataillade G, Couprie J, Moutiez M, Gondry M, Angulo JF, Zinn-Justin S. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. J Mol Biol. 2006 Dec 8;364(4):764-76. Epub 2006 Sep 16. PMID:17045609 doi:10.1016/j.jmb.2006.09.033