Structural highlights
Function
CSA5B_SACS2 CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In strain P2 toxic when expressed in vivo in the absence of CRISPR loci A-D (strain P2 contains 6 CRISPR loci in all). It causes strong growth inhibition, a significant proportion of cells have degraded or no DNA by 20-24 post-induction (PubMed:25277654).[1]
References
- ↑ He F, Chen L, Peng X. First experimental evidence for the presence of a CRISPR toxin in sulfolobus. J Mol Biol. 2014 Nov 11;426(22):3683-3688. PMID:25277654 doi:10.1016/j.jmb.2014.09.016
