9dum

Structural highlights

Function

WDR18_HUMAN Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity).[UniProtKB:Q68EI0]^{[1] [2]}

References

1. ↑ Finkbeiner E, Haindl M, Muller S. The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. EMBO J. 2011 Mar 16;30(6):1067-78. doi: 10.1038/emboj.2011.33. Epub 2011 Feb 15. PMID:21326211 doi:http://dx.doi.org/10.1038/emboj.2011.33
2. ↑ Fanis P, Gillemans N, Aghajanirefah A, Pourfarzad F, Demmers J, Esteghamat F, Vadlamudi RK, Grosveld F, Philipsen S, van Dijk TB. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Mol Cell Proteomics. 2012 Nov;11(11):1263-73. doi: 10.1074/mcp.M112.017194. Epub , 2012 Aug 7. PMID:22872859 doi:http://dx.doi.org/10.1074/mcp.M112.017194