Structural highlights
Function
EGTUB_STRP2 Part of an ABC transporter complex EgtU required for the uptake of ergothioneine (EGT), a natural low-molecular weight (LMW) thiol antioxidant (PubMed:36481738). Responsible for the translocation of the substrate across the membrane (PubMed:36481738). Also contains a C-terminal periplasmic solute-binding domain (SBD) which binds to EGT with sub-micromolar affinity (PubMed:36481738). Binds L-hercynine about 10,000-fold less tightly than EGT (PubMed:36481738). Cannot bind the structurally similar compounds L-histidine, proline-betaine, choline, ectoine, carnitine or dimethylpropiothetin (PubMed:36481738).[1]
References
- ↑ Zhang Y, Gonzalez-Gutierrez G, Legg KA, Walsh BJC, Pis Diez CM, Edmonds KA, Giedroc DP. Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine. Nat Commun. 2022 Dec 8;13(1):7586. doi: 10.1038/s41467-022-35277-3. PMID:36481738 doi:http://dx.doi.org/10.1038/s41467-022-35277-3
