9eke

Structural highlights

Function

SALO_LUTLO Salivary protein that inhibits the classical pathway of complement system activation in the host while having no inhibitory effect on the alternative or lectin pathways (PubMed:26758086, PubMed:28278244). Prevent cleavage of host C4 and consequently impairs the activation of factors downstream of C4b in the complement cascade (PubMed:26758086).^{[1] [2]}

References

1. ↑ Ferreira VP, Fazito Vale V, Pangburn MK, Abdeladhim M, Mendes-Sousa AF, Coutinho-Abreu IV, Rasouli M, Brandt EA, Meneses C, Lima KF, Nascimento Araújo R, Pereira MH, Kotsyfakis M, Oliveira F, Kamhawi S, Ribeiro JM, Gontijo NF, Collin N, Valenzuela JG. SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. Sci Rep. 2016 Jan 13;6:19300. PMID:26758086 doi:10.1038/srep19300
2. ↑ Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bartholomeu DC, Fujiwara RT, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG. Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. PLoS Negl Trop Dis. 2017 Mar 9;11(3):e0005374. doi: 10.1371/journal.pntd.0005374., eCollection 2017 Mar. PMID:28278244 doi:http://dx.doi.org/10.1371/journal.pntd.0005374