Structural highlights
Function
OYE2_YEAST Flavin-dependent enoate reductase that catalyzes the chemo- and stereoslective hydrogenation of electron-poor alkenes. The enzyme is reduced by NADPH, and oxygen, quinones, and alpha,beta-unsaturated aldehydes and ketones can act as electron acceptors to complete catalytic turnover. The physiological oxidant remains elusive (By similarity). Has an antioxidant activity, reducing reactive oxygen species (ROS) levels when overexpressed. Formation of OYE2-OYE3 heterodimers contribute to the induction of programmed cell death upon oxidative stress (PubMed:17897954).[UniProtKB:Q02899][1]
References
- ↑ Odat O, Matta S, Khalil H, Kampranis SC, Pfau R, Tsichlis PN, Makris AM. Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast. J Biol Chem. 2007 Dec 7;282(49):36010-23. PMID:17897954 doi:10.1074/jbc.M704058200
