9ftm
From Proteopedia
Asgard ESCRT-IIIB membrane-bound protofilament structure
Structural highlights
FunctionPublication Abstract from PubMedESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis, we demonstrate that the two endosomal sorting complex required for transport III (ESCRT-III) proteins present in eukaryote's closest Asgard archaeal relatives are evolutionarily related to the B- and A-type eukaryotic paralogs that initiate and execute membrane remodeling, respectively. We show that Asgard ESCRT-IIIB assembles into parallel arrays on planar membranes to initiate membrane deformation, from where it recruits ESCRT-IIIA to generate composite polymers. Last, we show that Asgard ESCRT-IIIA is able to remodel membranes into tubes as a likely prelude to scission. Together, these data reveal a set of conserved principles governing ESCRT-III-dependent membrane remodeling that first emerged in a two-component ESCRT-III system in archaea. Asgard archaea reveal the conserved principles of ESCRT-III membrane remodeling.,Souza DP, Espadas J, Chaaban S, Moody ERR, Hatano T, Balasubramanian M, Williams TA, Roux A, Baum B Sci Adv. 2025 Feb 7;11(6):eads5255. doi: 10.1126/sciadv.ads5255. Epub 2025 Feb 7. PMID:39919172[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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