Structural highlights
Function
UVRA_MYCTU The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange.[1] [2]
References
- ↑ Singh P, Patil KN, Khanduja JS, Kumar PS, Williams A, Rossi F, Rizzi M, Davis EO, Muniyappa K. Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins. Biochemistry. 2010 Jun 15;49(23):4872-83. doi: 10.1021/bi902021d. PMID:20455546 doi:http://dx.doi.org/10.1021/bi902021d
- ↑ Houghton J, Townsend C, Williams AR, Rodgers A, Rand L, Walker KB, Bottger EC, Springer B, Davis EO. Important role for Mycobacterium tuberculosis UvrD1 in pathogenesis and persistence apart from its function in nucleotide excision repair. J Bacteriol. 2012 Jun;194(11):2916-23. doi: 10.1128/JB.06654-11. Epub 2012 Mar, 30. PMID:22467787 doi:http://dx.doi.org/10.1128/JB.06654-11
