9gtv

Structural highlights

Function

HTHTR_SALTY Transcriptional regulator (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Represses the transcription of the transcriptional activator RamA and, thereby, leads to repression of the expression of the efflux pump subunits AcrA and AcrB, and TolC (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Acts by binding directly to the promoter region of the ramA gene (PubMed:22123696, PubMed:22948865, PubMed:23800819). Promoter binding may be inhibited partially by the small regulatory RNA StyR3, perhaps thereby ensuring a basal level of expression of RamA.[UniProtKB:A0A0H3GJQ8]^{[1] [2] [3] [4] [5]}

References

1. ↑ Abouzeed YM, Baucheron S, Cloeckaert A. ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2008 Jul;52(7):2428-34. PMID:18443112 doi:10.1128/AAC.00084-08
2. ↑ Baucheron S, Coste F, Canepa S, Maurel MC, Giraud E, Culard F, Castaing B, Roussel A, Cloeckaert A. Binding of the RamR repressor to wild-type and mutated promoters of the RamA gene involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2012 Feb;56(2):942-8. PMID:22123696 doi:10.1128/AAC.05444-11
3. ↑ Ricci V, Busby SJ, Piddock LJ. Regulation of RamA by RamR in Salmonella enterica serovar Typhimurium: isolation of a RamR superrepressor. Antimicrob Agents Chemother. 2012 Nov;56(11):6037-40. PMID:22948865 doi:10.1128/AAC.01320-12
4. ↑ Yamasaki S, Nikaido E, Nakashima R, Sakurai K, Fujiwara D, Fujii I, Nishino K. The crystal structure of multidrug-resistance regulator RamR with multiple drugs. Nat Commun. 2013 Jun 26;4:2078. doi: 10.1038/ncomms3078. PMID:23800819 doi:10.1038/ncomms3078
5. ↑ Yamasaki S, Nakashima R, Sakurai K, Baucheron S, Giraud E, Doublet B, Cloeckaert A, Nishino K. Crystal structure of the multidrug resistance regulator RamR complexed with bile acids. Sci Rep. 2019 Jan 17;9(1):177. doi: 10.1038/s41598-018-36025-8. PMID:30655545 doi:http://dx.doi.org/10.1038/s41598-018-36025-8