Structural highlights
9gvu is a 4 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.1Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
RB27A_HUMAN Griscelli syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry.
Function
RB27A_HUMAN Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.[1]
References
- ↑ Menasche G, Menager MM, Lefebvre JM, Deutsch E, Athman R, Lambert N, Mahlaoui N, Court M, Garin J, Fischer A, de Saint Basile G. A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion. Blood. 2008 Dec 15;112(13):5052-62. doi: 10.1182/blood-2008-02-141069. Epub 2008 , Sep 23. PMID:18812475 doi:http://dx.doi.org/10.1182/blood-2008-02-141069
