Structural highlights
Function
PG040_VACCW Negatively regulates superinfection and syncytium formation in infected host cells. Acts in concert with OPG185/A56 protein at the host cell membrane by interacting with and inhibiting the mature virion entry/fusion complex (EFC). This mechanism ensures that new virions released from the cell cannot enter already infected cells.[1]
References
- ↑ Cotter CA, Moss B. Mutations Near the N Terminus of Vaccinia Virus G9 Protein Overcome Restrictions on Cell Entry and Syncytium Formation Imposed by the A56/K2 Fusion Regulatory Complex. J Virol. 2020 May 4;94(10):e00077-20. PMID:32132239 doi:10.1128/JVI.00077-20
