9hle

Structural highlights

Function

MCTB_MYCTU Pore-forming protein, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence.^{[1] [2]}

References

1. ↑ Siroy A, Mailaender C, Harder D, Koerber S, Wolschendorf F, Danilchanka O, Wang Y, Heinz C, Niederweis M. Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins. J Biol Chem. 2008 Jun 27;283(26):17827-37. PMID:18434314 doi:10.1074/jbc.M800866200
2. ↑ Wolschendorf F, Ackart D, Shrestha TB, Hascall-Dove L, Nolan S, Lamichhane G, Wang Y, Bossmann SH, Basaraba RJ, Niederweis M. Copper resistance is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1621-6. PMID:21205886 doi:10.1073/pnas.1009261108