9hma

Structural highlights

Function

ESPL1_HUMAN Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.^{[1] [2]}

References

1. ↑ Zou H, McGarry TJ, Bernal T, Kirschner MW. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science. 1999 Jul 16;285(5426):418-22. PMID:10411507 doi:10.1126/science.285.5426.418
2. ↑ Hauf S, Waizenegger IC, Peters JM. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science. 2001 Aug 17;293(5533):1320-3. PMID:11509732 doi:10.1126/science.1061376