9hpa

Structural highlights

Function

PG143_VACCW Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation).^{[1] [2]}

References

1. ↑ Ojeda S, Senkevich TG, Moss B. Entry of vaccinia virus and cell-cell fusion require a highly conserved cysteine-rich membrane protein encoded by the A16L gene. J Virol. 2006 Jan;80(1):51-61. PMID:16352530 doi:10.1128/JVI.80.1.51-61.2006
2. ↑ Chang SJ, Shih AC, Tang YL, Chang W. Vaccinia mature virus fusion regulator A26 protein binds to A16 and G9 proteins of the viral entry fusion complex and dissociates from mature virions at low pH. J Virol. 2012 Apr;86(7):3809-18. PMID:22278246 doi:10.1128/JVI.06081-11