Structural highlights
Function
TSN10_HUMAN Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates.[1]
References
- ↑ Lipper CH, Egan ED, Gabriel KH, Blacklow SC. Structural basis for membrane-proximal proteolysis of substrates by ADAM10. Cell. 2023 Aug 17;186(17):3632-3641.e10. PMID:37516108 doi:10.1016/j.cell.2023.06.026
