9i2s

Structural highlights

Function

VEA_EMENI Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:12223191, PubMed:14665453, PubMed:18556559, PubMed:19210625, PubMed:2076818, PubMed:2253875). The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:18556559). Controls the expression of the sterigmatocystin and penicillin gene clusters (PubMed:14665453, PubMed:17375284). Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner (PubMed:23841751). Required for full induction of faoA gene expression by fructosyl amines (PubMed:12375102). Positively regulates the expression of the early sexual development gene esdC (PubMed:17977758). Controls the expression of mannoprotein mnpA (PubMed:12620259).^{[1] [2] [3] [4] [5] [6] [7] [8] [9] [10]}

References

1. ↑ Kim H, Han K, Kim K, Han D, Jahng K, Chae K. The veA gene activates sexual development in Aspergillus nidulans. Fungal Genet Biol. 2002 Oct;37(1):72-80. PMID:12223191 doi:10.1016/s1087-1845(02)00029-4
2. ↑ Jeong HY, Song MH, Back JH, Han DM, Wu X, Monnier V, Jahng KY, Chae KS. The veA gene is necessary for the inducible expression by fructosyl amines of the Aspergillus nidulans faoA gene encoding fructosyl amino acid oxidase (amadoriase, EC 1.5.3). Arch Microbiol. 2002 Nov;178(5):344-50. PMID:12375102 doi:10.1007/s00203-002-0463-x
3. ↑ Jeong HY, Kim H, Han DM, Jahng KY, Chae KS. Expression of the mnpA gene that encodes the mannoprotein of Aspergillus nidulans is dependent on fadA and flbA as well as veA. Fungal Genet Biol. 2003 Mar;38(2):228-36. PMID:12620259 doi:10.1016/s1087-1845(02)00527-3
4. ↑ Kato N, Brooks W, Calvo AM. The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development. Eukaryot Cell. 2003 Dec;2(6):1178-86. PMID:14665453 doi:10.1128/EC.2.6.1178-1186.2003
5. ↑ Han KH, Kim JH, Moon H, Kim S, Lee SS, Han DM, Jahng KY, Chae KS. The Aspergillus nidulans esdC (early sexual development) gene is necessary for sexual development and is controlled by veA and a heterotrimeric G protein. Fungal Genet Biol. 2008 Mar;45(3):310-8. PMID:17977758 doi:10.1016/j.fgb.2007.09.008
6. ↑ Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science. 2008 Jun 13;320(5882):1504-6. PMID:18556559 doi:10.1126/science.1155888
7. ↑ Bayram O, Sari F, Braus GH, Irniger S. The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans. Mol Microbiol. 2009 Mar;71(5):1278-95. PMID:19210625 doi:10.1111/j.1365-2958.2009.06606.x
8. ↑ Mooney JL, Hassett DE, Yager LN. Genetic analysis of suppressors of the veA1 mutation in Aspergillus nidulans. Genetics. 1990 Dec;126(4):869-74. PMID:2076818 doi:10.1093/genetics/126.4.869
9. ↑ Mooney JL, Yager LN. Light is required for conidiation in Aspergillus nidulans. Genes Dev. 1990 Sep;4(9):1473-82. PMID:2253875 doi:10.1101/gad.4.9.1473
10. ↑ Bok JW, Soukup AA, Chadwick E, Chiang YM, Wang CC, Keller NP. VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation. Mol Microbiol. 2013 Sep;89(5):963-74. PMID:23841751 doi:10.1111/mmi.12326