Structural highlights
Function
LYSC_CHICK Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.[1]
Publication Abstract from PubMed
Crystals of the model protein lysozyme were grown and soaked with the potential drug V(IV)O(acetylacetonato)(2) at 37 degrees C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.
Formation of Mixed-Valence Cage-Like Polyoxidovanadates at 37 degrees C Upon Reaction of V(IV)O(acetylacetonato)(2) With Lysozyme.,Tito G, Ferraro G, Garribba E, Merlino A Chemistry. 2025 Apr 24:e202500488. doi: 10.1002/chem.202500488. PMID:40271720[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
- ↑ Tito G, Ferraro G, Garribba E, Merlino A. Formation of Mixed-Valence Cage-Like Polyoxidovanadates at 37°C Upon Reaction of V(IV)O(acetylacetonato)(2) With Lysozyme. Chemistry. 2025 Apr 24:e202500488. PMID:40271720 doi:10.1002/chem.202500488
