Structural highlights
Function
ALGLR_THEMA Catalyzes the racemization of L-alanine to D-alanine, and of L-glutamate to D-glutamate. The activity is low, but likely physiological since T.maritima lacks canonical alr and murI genes, while D-alanine and D-glutamate are essential components of peptidoglycan. Also displays a more efficient cystathionine beta-lyase (CBL) activity, cleaving cystathionine to homocysteine and pyruvate; however, this reaction seems not to be physiologically relevant since T.maritima possesses an O-acetyl-homoserine thiolase (MetY) that bypasses the need of CBL for methionine biosynthesis. Is not able to produce cystathionine, using either O-acetylhomoserine or O-succinylhomoserine, plus L-cysteine as substrates, and thus does not possess cystathionine gamma-synthase (CGS) activity.[1]
References
- ↑ Ferla MP, Brewster JL, Hall KR, Evans GB, Patrick WM. Primordial-like enzymes from bacteria with reduced genomes. Mol Microbiol. 2017 Aug;105(4):508-524. doi: 10.1111/mmi.13737. Epub 2017 Jul 6. PMID:28640457 doi:http://dx.doi.org/10.1111/mmi.13737
