9j1o

Structural highlights

Function

SPIB_MOUSE Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.^{[1] [2] [3] [4] [5] [6] [7]}

References

1. ↑ Garrett-Sinha LA, Su GH, Rao S, Kabak S, Hao Z, Clark MR, Simon MC. PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. Immunity. 1999 Apr;10(4):399-408. PMID:10229183 doi:10.1016/s1074-7613(00)80040-0
2. ↑ Garrett-Sinha LA, Dahl R, Rao S, Barton KP, Simon MC. PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood. 2001 May 1;97(9):2908-12. PMID:11313289 doi:10.1182/blood.v97.9.2908
3. ↑ Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC. PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity. 2001 Oct;15(4):545-55. PMID:11672537 doi:10.1016/s1074-7613(01)00219-9
4. ↑ Dahl R, Ramirez-Bergeron DL, Rao S, Simon MC. Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 2002 May 1;21(9):2220-30. PMID:11980719 doi:10.1093/emboj/21.9.2220
5. ↑ Kim N, Martin TE, Simon MC, Storb U. The transcription factor Spi-B is not required for somatic hypermutation. Mol Immunol. 2003 Jan;39(10):577-83. PMID:12431391 doi:10.1016/s0161-5890(02)00201-8
6. ↑ Su GH, Ip HS, Cobb BS, Lu MM, Chen HM, Simon MC. The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. J Exp Med. 1996 Jul 1;184(1):203-14. PMID:8691135 doi:10.1084/jem.184.1.203
7. ↑ Su GH, Chen HM, Muthusamy N, Garrett-Sinha LA, Baunoch D, Tenen DG, Simon MC. Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. EMBO J. 1997 Dec 1;16(23):7118-29. PMID:9384589 doi:10.1093/emboj/16.23.7118