Structural highlights
Function
FRDA_ARATH Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways (PubMed:17092311). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+) (PubMed:17092311). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (PubMed:17092311). Binds to the mitochondrial cysteine desulfurase NIFS1 and increases its activity (PubMed:22511606).[1] [2]
References
- ↑ Busi MV, Maliandi MV, Valdez H, Clemente M, Zabaleta EJ, Araya A, Gomez-Casati DF. Deficiency of Arabidopsis thaliana frataxin alters activity of mitochondrial Fe-S proteins and induces oxidative stress. Plant J. 2006 Dec;48(6):873-82. PMID:17092311 doi:10.1111/j.1365-313X.2006.02923.x
- ↑ Turowski VR, Busi MV, Gomez-Casati DF. Structural and functional studies of the mitochondrial cysteine desulfurase from Arabidopsis thaliana. Mol Plant. 2012 Sep;5(5):1001-10. PMID:22511606 doi:10.1093/mp/sss037
