9jn9
From Proteopedia
Cryo-EM structure of human SLFN14
Structural highlights
DiseaseSLN14_HUMAN Autosomal dominant thrombocytopenia with platelet secretion defect. The disease is caused by variants affecting the gene represented in this entry. FunctionSLN14_HUMAN Shows no ribosome-associated and endoribonuclease activities.[1] Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.[UniProtKB:G1SRW8][2] [3] [4] References
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Categories: Homo sapiens | Large Structures | Gao S | Jia XD | Luo M | Wang ZW | Yang JY | Zhang QF
