Structural highlights
Function
VDAC1_YEAST Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane (PubMed:9435273). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:9435273). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:9435273). Is the major permeability factor of the mitochondrial outer membrane (PubMed:9435273).[1] Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids.[2]
References
- ↑ Lee AC, Xu X, Blachly-Dyson E, Forte M, Colombini M. The role of yeast VDAC genes on the permeability of the mitochondrial outer membrane. J Membr Biol. 1998 Jan 15;161(2):173-81. PMID:9435273 doi:10.1007/s002329900324
- ↑ Jahn H, Bartoš L, Dearden GI, Dittman JS, Holthuis JCM, Vácha R, Menon AK. Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase. Nat Commun. 2023 Dec 8;14(1):8115. PMID:38065946 doi:10.1038/s41467-023-43570-y
