9k49

Structural highlights

Function

TOLQ_ECOLI Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity (PubMed:1683466, PubMed:17233825). Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction (PubMed:11722743). The Tol-Pal system is also required for polar localization of chemoreceptors clusters (PubMed:24720726). The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity (PubMed:32152098). Is involved in the uptake of group A colicins (colicins A, E1, E2, E3, and K) and in the uptake of filamentous phage DNA (PubMed:1683466, PubMed:3294803).^{[1] [2] [3] [4] [5] [6] [7]}

References

1. ↑ Cascales E, Lloubès R, Sturgis JN. The TolQ-TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA-MotB. Mol Microbiol. 2001 Nov;42(3):795-807. PMID:11722743 doi:10.1046/j.1365-2958.2001.02673.x
2. ↑ Webster RE. The tol gene products and the import of macromolecules into Escherichia coli. Mol Microbiol. 1991 May;5(5):1005-11. PMID:1683466 doi:10.1111/j.1365-2958.1991.tb01873.x
3. ↑ Gerding MA, Ogata Y, Pecora ND, Niki H, de Boer PA. The trans-envelope Tol-Pal complex is part of the cell division machinery and required for proper outer-membrane invagination during cell constriction in E. coli. Mol Microbiol. 2007 Feb;63(4):1008-25. PMID:17233825 doi:10.1111/j.1365-2958.2006.05571.x
4. ↑ Santos TM, Lin TY, Rajendran M, Anderson SM, Weibel DB. Polar localization of Escherichia coli chemoreceptors requires an intact Tol-Pal complex. Mol Microbiol. 2014 Jun;92(5):985-1004. PMID:24720726 doi:10.1111/mmi.12609
5. ↑ Yakhnina AA, Bernhardt TG. The Tol-Pal system is required for peptidoglycan-cleaving enzymes to complete bacterial cell division. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6777-6783. PMID:32152098 doi:10.1073/pnas.1919267117
6. ↑ Sun TP, Webster RE. Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli. J Bacteriol. 1987 Jun;169(6):2667-74. PMID:3294803 doi:10.1128/jb.169.6.2667-2674.1987
7. ↑ Webster RE. The tol gene products and the import of macromolecules into Escherichia coli. Mol Microbiol. 1991 May;5(5):1005-11. PMID:1683466 doi:10.1111/j.1365-2958.1991.tb01873.x