9kk3

Structural highlights

Function

CM3K_CONRA Kappa-conotoxins inhibits voltage-gated potassium channels (Kv). This synthetic toxin reversibly inhibits the insect potassium channel Shaker K+, the teleost homolog TSha1 and the mammalian Kv1.2/KCNA2 channel. Interacts with the pore region of the insect channel, in a state-dependent manner. Causes seizure when intracerebrovascularly injected into mice. Is also toxic when intrathecally injected into mice, but shows no visible effects by intraperitoneal injection. Shows protective effects on cardiac tissue when administered after an ischemic event.^{[1] [2]}

References

1. ↑ Ferber M, Sporning A, Jeserich G, DeLaCruz R, Watkins M, Olivera BM, Terlau H. A novel conus peptide ligand for K+ channels. J Biol Chem. 2003 Jan 24;278(4):2177-83. PMID:12399472 doi:10.1074/jbc.M205953200
2. ↑ Chen P, Dendorfer A, Finol-Urdaneta RK, Terlau H, Olivera BM. Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem. 2010 May 14;285(20):14882-14889. PMID:20220134 doi:10.1074/jbc.M109.068486